Problems in cerebral blood flow calculation using xenon-133 in patients with pulmonary diseases
- Odense Univ. Hospital (Denmark)
We used the end-tidal concentration of xenon-133 (air curve) to estimate the profile of its arterial concentration in calculating cerebral blood flow. We examined the effects of pulmonary disease and artificial ventilation on the air curve and the calculated cerebral blood flow. We studied the relation between arterial and end-tidal xenon activities in 19 subjects, of whom 15 had pulmonary dysfunction. The t 1/2 of the declining phases of the arterial and air curves were used to express their shapes. The mean +/- SD reference t 1/2 from 15 normal volunteers was 26.8 +/- 8.4 seconds. The mean +/- SD t 1/2 s of the air and arterial curves from the 15 patients with pulmonary dysfunction were 10.4 +/- 2.9 and 33.8 +/- 10.9 seconds. The degree of pulmonary dysfunction (expressed as the pulmonary shunt percentage) correlated with distortion of the air curve. Substituting the arterial for the air curve, mean calculated cerebral blood flow (as the initial slope index) increased from 40 to 61 for the 12 patients with chronic obstructive pulmonary disease. The degree of underestimation of cerebral blood flow using the air curve correlated with the pulmonary shunt percentage. Our work confirms the problems of estimating cerebral blood flow in subjects with pulmonary dysfunction.
- OSTI ID:
- 7015914
- Journal Information:
- Stroke; (USA), Journal Name: Stroke; (USA) Vol. 21:5; ISSN SJCCA; ISSN 0039-2499
- Country of Publication:
- United States
- Language:
- English
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Conference
·
Sat Dec 31 23:00:00 EST 1983
· J. Nucl. Med.; (United States)
·
OSTI ID:6930173
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Thu Oct 30 23:00:00 EST 1958
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Fri Jul 01 00:00:00 EDT 1983
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OSTI ID:6726571
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANS
OXYGEN
PATIENTS
PRIMATES
RADIOISOTOPES
RESPIRATORY SYSTEM DISEASES
VEINS
VERTEBRATES
XENON 133
XENON ISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
ELEMENTS
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANS
OXYGEN
PATIENTS
PRIMATES
RADIOISOTOPES
RESPIRATORY SYSTEM DISEASES
VEINS
VERTEBRATES
XENON 133
XENON ISOTOPES