A NEW DIAGNOSTIC METHOD IN THE STUDY OF CONGENITAL HEART DISEASE: THE KRYPTON$sup 85$ TEST FOR CIRCULATORY SHUNTS

Technical Report · Fri Oct 31 04:00:00 EST 1958

OSTI ID:4309898

A new method is presented for determnining the presence or absence of a left-to-right circulatory shunt in patients with congenital heart disease. In the course of right heart catheterizatioq patients inhaled a mixture of kryption/ sup 85/ and air for 30 seconds, as blood samples were drawn simultaneously from the pulmonary artery and from a systemic artery. It was found that when the radioactivity of pulmonary arterial blood was more than 20 per cent of the systemic arterial level, the diagnosis of a shunt could be made; when less than 10 per cent the absence of a shunt was confirmed, and tests between 10 and 20 per cent wcre considered inconclusive and were repeated. The blood samples were analyzed with a gss flow counter and scaler, and the results were available within five minutes. When the pulmonary artery test was positive, the test was repeated in the right ventricle and right atriumn to localize the shunt. The advantages of the Kr/su p85/ test over the method employing blood oxygen differences was demonstrated in 52 patients studied by both methods. There were six diagnostic errors with the orygen method and none with Kr/sup 35/. (auth)

• Research Organization: National Heart Inst., Bethesda, Md.
• NSA Number: NSA-12-014582
• OSTI ID: 4309898
• Report Number(s): A/CONF.15/P/866
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AIR
BIOLOGY AND MEDICINE
BLOOD
BLOOD CIRCULATION
BLOOD VESSELS
CONFERENCE
COUNTERS
DIAGNOSIS
DISEASES
ERRORS
GAS FLOW
HEART
KRYPTON 85
LUNGS
MAN
MEDICINE
OXYGEN
RADIOACTIVITY
SAMPLING
SCALERS
STATISTICS
TESTING
VARIATIONS