Altered host resistance to Listeria monocytogenes in mice exposed to 1-chloroacetophenone (CN) vapours
Journal Article
·
· Biomedical and Environmental Sciences; (United States)
OSTI ID:7013404
- Defence Research and Development Establishment, Gwalior (India)
Short term repeated exposure of 1-chloroacetophenone (CN) vapours at a concentration of 0.153 mg per litre for 15 minutes daily on 10 consecutive days in Swiss albino male mice resulted in increased mortality to Listeria monocytogenes. Significantly elevated bacterial growth was observed in the spleen and liver of the CN exposed animals. The increased bacterial count in these organs was evident within 4-6 days post challenge as compared to vehicle exposed infected and unexposed infected animals. Increased susceptibility to infection has been considered to be the function of immune alteration due to cumulative short term effects of CN vapour inhalation. This may be attributed to immunotoxic effects of CN on T-cells mediated macrophage functions.
- OSTI ID:
- 7013404
- Journal Information:
- Biomedical and Environmental Sciences; (United States), Journal Name: Biomedical and Environmental Sciences; (United States) Vol. 5:2; ISSN 0895-3988; ISSN BESCE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETOPHENONE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASE RESISTANCE
DISEASES
ENVIRONMENTAL EXPOSURE
FLUIDS
GASES
GLANDS
IMMUNITY
INFECTIOUS DISEASES
KETONES
LEUKOCYTES
LIVER
LYMPHOCYTES
MACROPHAGES
MAMMALS
MATERIALS
MICE
MORTALITY
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PHAGOCYTES
RETICULOENDOTHELIAL SYSTEM
RODENTS
SENSITIVITY
SOMATIC CELLS
SPLEEN
TISSUES
VAPORS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETOPHENONE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BACTERIAL DISEASES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DISEASE RESISTANCE
DISEASES
ENVIRONMENTAL EXPOSURE
FLUIDS
GASES
GLANDS
IMMUNITY
INFECTIOUS DISEASES
KETONES
LEUKOCYTES
LIVER
LYMPHOCYTES
MACROPHAGES
MAMMALS
MATERIALS
MICE
MORTALITY
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PHAGOCYTES
RETICULOENDOTHELIAL SYSTEM
RODENTS
SENSITIVITY
SOMATIC CELLS
SPLEEN
TISSUES
VAPORS
VERTEBRATES