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Enhancement of host resistance against Listeria infection by Lactobacillus casei: Role of macrophages

Journal Article · · Infect. Immun.; (United States)
OSTI ID:6816304
Among the 10 species of the genus Lactobacillus, L. casei showed the strongest protective action against Listeria monocytogenes infection in mice. The activity of L. casei differed with regard to the dose of administration. The anti-L. monocytogenes resistance in mice intravenously administered 5.5 X 10(7), 2.8 X 10(8), or 1.1 X 10(9) L. casei cells was most manifest at ca. 2, 2 and 13, and 3 to 21 days after its administration, respectively. The growth of L. monocytogenes in the liver of mice injected with L. casei (10(7), 10(8), or 10(9) cells) 48 h after infection was suppressed, particularly when 10(8) or 10(9) L. casei cells were given 2 or 13 days before the induced infection, respectively. This suppression of L. monocytogenes growth was overcome by carrageenan treatment or X-ray irradiation. (/sup 3/H)thymidine incorporation into the liver DNA increased 13 days after administration of L. casei, and augmentation of (/sup 3/H)thymidine incorporation during 6 to 48 h after infection was dependent on the dose of L. casei. Peritoneal macrophage accumulation observed 1 to 5 days after intraperitoneal injection of UV-killed L. monocytogenes was markedly enhanced when the mice were treated with L. casei cells 13 days before macrophage elicitation. Therefore, the enhanced host resistance by L. casei to L. monocytogenes infection may be mediated by macrophages migrating from the blood stream to the reticuloendothelial system in response to L. casei injection before or after L. monocytogenes infection.
Research Organization:
Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan
OSTI ID:
6816304
Journal Information:
Infect. Immun.; (United States), Journal Name: Infect. Immun.; (United States) Vol. 44:2; ISSN INFIB
Country of Publication:
United States
Language:
English

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Related Subjects

550901 -- Pathology-- Tracer Techniques
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AZINES
BACILLUS
BACTERIA
CONNECTIVE TISSUE CELLS
DISEASE RESISTANCE
DISEASES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
INFECTIOUS DISEASES
IONIZING RADIATIONS
LABELLED COMPOUNDS
MACROPHAGES
MAMMALS
MICE
MICROORGANISMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHAGOCYTES
PYRIMIDINES
RADIATIONS
RIBOSIDES
RODENTS
SOMATIC CELLS
THYMIDINE
TRITIUM COMPOUNDS
VERTEBRATES
X RADIATION