Preclinical neurophysiological signs of parkinsonism in occupational manganese exposure

Journal Article · · Neurotoxicology (Park Forest South, Illinois); (United States)

OSTI ID:7013371

Wennberg, A; Hagman, M; Johansson, L ^[1]

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1. Department of Neuromedicine, National Institute of Occupational Health, Solna (Sweden)

To study the effects from low level exposure to manganese, 30 men at steel smelting works and 60 nonexposed reference subjects, were neurophysiologically examined using: (i) Electroencephalogram (EEG), Event related auditory evoked potential (AEP/P300), Brain stem auditory evoked potential (BAEP) and diadochokinesometry. No group differences concerning EEG or BAEP were found. Diadochokinesis was slower and there was a tendency towards prolonged P300 latency in the exposed group as compared to the referents. These effects may be interpreted as early (subclinical) signs of disturbances of the same type as parkinsonism.

• OSTI ID: 7013371
• Journal Information: Neurotoxicology (Park Forest South, Illinois); (United States), Journal Name: Neurotoxicology (Park Forest South, Illinois); (United States) Vol. 13:1; ISSN 0161-813X; ISSN NRTXD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROENCEPHALOGRAPHY
ELEMENTS
HAZARDS
HEALTH HAZARDS
MAMMALS
MAN
MANGANESE
METALLURGY
METALS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
OCCUPATIONAL DISEASES
ORGANS
PATHOGENESIS
PRIMATES
TRANSITION ELEMENTS
VERTEBRATES