Evaluation of brain function in acute carbon monoxide poisoning with multimodality evoked potentials

Journal Article · Mon Feb 01 04:00:00 EST 1993 · Environmental Research; (United States)

DOI:https://doi.org/10.1006/enrs.1993.1029· OSTI ID:6586290

He, Fengsheng; Liu, Xibao; Yang, Shi; Zhang, Shoulin ^[1]; Xu, Guanghua; Fang, Guangchai; Pan, Xiaowen ^[2]

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1. Institute of Occupational Medicine, Beijing (China)
2. Navy Hospital, Beijing (China)

The median nerve somatosensory evoked potentials (SEP), pattern reversal visual evoked potentials (VEP), and brain stem auditory evoked potentials (BAEP) were studied in 109 healthy adults and in 88 patients with acute carbon monoxide (CO) poisoning. The upper limits for normal values of peak and interpeak latencies of multimodalities of evoked potentials in the reference group were established by a stepwise multiple regression analysis. SEP changes selectively affecting N32 and N60 were found in 78.8% of patients. There was prolonged PI00 latency of VEP in 58.2% of the cases examined. The prevalence of BAEP abnormalities in comatose patients (36%) was significantly higher than that (8.6%) in conscious patients. BAEP abnormalities were most frequently seen in comatose patients who had diminished brain stem reflexes (77.8%). It has been found that a consistent abnormality involving N2O and subsequent peaks in SEP, a remarkable prolongation of PI00 latency in VEP, or a prolongation of Ill-V interpeak latency in BAEP as well as the reoccurrence of evoked potential abnormalities after initial recovery all indicate unfavorable outcomes in patients with acute CO poisoning. The multimodality evoked potentials have proved to be sensitive indicators in the evaluation of brain dysfunction and in the prediction of prognosis of acute CO poisoning and the development of delayed encephalopathy. 16 refs., 4 figs., 6 tabs.

• OSTI ID: 6586290
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 60:2; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ADULTS
AGE GROUPS
AIR POLLUTION
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
DIAGNOSTIC TECHNIQUES
DISEASE INCIDENCE
DISEASES
ELECTRIC POTENTIAL
ELECTROPHYSIOLOGY
ENCEPHALITIS
INDOOR AIR POLLUTION
INFECTIOUS DISEASES
MATHEMATICS
MENTAL DISORDERS
MORTALITY
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHYSIOLOGY
POISONING
POLLUTION
REGRESSION ANALYSIS
STATISTICS
VIRAL DISEASES