Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes

Journal Article · Mon Jun 01 04:00:00 EDT 1992 · Journal of Immunology; (United States)

OSTI ID:7009437

Kim, J M; Khan, T A; Moore, K W ^[1]; Brannan, C I; Copeland, N G; Jenkins, N A ^[2]

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1. DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA (United States)
2. National Cancer Institute, Frederick, MD (United States)

The nucleotide sequence of a 7.2-kb segment containing the mouse IL-10 (mIL-10) gene was determined. Comparison to the mIL-10 cDNA sequence revealed the presence of five exons that span [approximately]5.1 kb of genomic DNA. The noncoding regions of the mIL-10 gene contain sequences that have been associated with transcriptional regulation of several cytokine genes. The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1. 35 refs., 4 figs., 3 tabs.

• OSTI ID: 7009437
• Journal Information: Journal of Immunology; (United States), Journal Name: Journal of Immunology; (United States) Vol. 148:11; ISSN JOIMA3; ISSN 0022-1767
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
DNA SEQUENCING
GENES
GENETIC MAPPING
GROWTH FACTORS
HUMAN CHROMOSOME 1
HUMAN CHROMOSOMES
LYMPHOKINES
MAPPING
MITOGENS
ORGANIC COMPOUNDS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS