Effects of opiates on synaptosomal calmodulin and calcium uptake

Journal Article · Tue Feb 01 04:00:00 EST 1983 · Neurochem. Res.; (United States)

DOI:https://doi.org/10.1007/BF00963922· OSTI ID:7005599

Hoss, W; Formaniak, M

Acute opiate administration in vivo increases the level of cytoplasmic calmodulin in isolated rat brain synaptosomes. These synaptosomes do not, however, display decreased K/sup +/-stimulated /sup 45/Ca uptake in vitro. Opiates affect neither cytoplasmic calmodulin nor Ca uptake after incubation of synaptosomes with the drugs in vitro. In contrast to the interpretation of electrophysiological data, these results suggest that the observed inhibition by opiates of the release of several transmitters may not be mediated by presynaptic opiate receptors that inhibit Ca uptake.

• Research Organization: Univ. of Rochester School of Medicine and Dentistry, NY
• OSTI ID: 7005599
• Journal Information: Neurochem. Res.; (United States), Journal Name: Neurochem. Res.; (United States) Vol. 8:2; ISSN NERED
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BRAIN
CALCIUM 45
CALCIUM ISOTOPES
CATIONS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DRUGS
EVEN-ODD NUCLEI
INHIBITION
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPES
MAMMALS
NARCOTICS
NERVE CELLS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ORGANS
POTASSIUM COMPOUNDS
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
SOMATIC CELLS
UPTAKE
VERTEBRATES