Nickel absorption and kinetics in human volunteers

Technical Report · Sun Jan 01 04:00:00 EST 1989

OSTI ID:7005190

Sunderman, F W; Hopfer, S M; Sweeney, K R; Marcus, A H; Most, B M

Mathematical modeling was performed of the kinetics of nickel absorption, distribution and elimination in healthy human volunteers, who ingested NiSO4 in drinking water or added food. Nickel was analyzed by electrothermal atomic absorption spectrophotometry in serum, urine, and feces collected during 2 days before and 4 days after a specified NiSO4 dose (12 ug Ni/kg, N=4; 18 ug Ni/kg, N=4; or 50 ug Ni/kg, N=1). The study confirms that dietary constituents profoundly reduce the bioavailability of Ni2+ for alimentary absorption; approximately one-quarter of nickel ingested in drinking water after an over-night fast is absorbed from the human intestine and excreted in urine, compared to only one percent of nickel ingested in food. The compartmental model and kinetic parameters provided by the study will reduce the uncertainty of toxicological risk assessments of human exposures to nickel in drinking water and food.

• Research Organization: Connecticut Univ., Farmington, CT (USA). School of Medicine
• OSTI ID: 7005190
• Report Number(s): PB-90-198094/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION SPECTRA
ANIMALS
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY
BODY FLUIDS
ELEMENTS
ENVIRONMENTAL EXPOSURE PATHWAY
FECES
KIDNEYS
MAMMALS
MAN
MATERIALS
MATHEMATICAL MODELS
METABOLISM
METALS
NICKEL
ORGANS
PRIMATES
SPECTRA
TOXICITY
TRANSITION ELEMENTS
URINE
VERTEBRATES
WASTES