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Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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The authors have isolated a human thrombomodulin cDNA, and a human genomic clone containing the putative promoter domain, as well as the translated and untranslated regions of the endothelial cell receptor. The nucleotide sequence of the thrombomodulin cDNA allows us to provide a complete picture of the structure of this endothelial cell receptor, and to confirm its homology to the human low density lipoprotein receptor. The nucleotide sequence of the thrombomodulin gene suggest areas within the putative promoter domain that may be critical for regulating expression of the human endothelial cell receptor, indicates a potential signal peptide, and shows that no introns are present within the coding region. The overall organization of the human thrombomodulin gene is surprising because it represents an example of a gene that contains epidermal growth factor type B repeats and a membrane spanning region, which are not isolated within discrete exons.

Research Organization:
Massachusetts Institute of Technology, Cambridge (USA)
OSTI ID:
6999931
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 84:18; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
AUTORADIOGRAPHY
BODY
COAGULANTS
DNA
DNA SEQUENCING
DRUGS
ELECTROPHORESIS
ENDOTHELIUM
ENZYMES
GENE REPRESSORS
GROWTH FACTORS
HEMATOLOGIC AGENTS
HEMOSTATICS
HYDROLASES
MEMBRANE PROTEINS
MITOGENS
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PROTEINS
RECEPTORS
RECOMBINANT DNA
SERINE PROTEINASES
STRUCTURAL CHEMICAL ANALYSIS
THROMBIN
TISSUES
TRANSCRIPTION