Sequence of a cDNA for mouse thrombomodulin and comparison of the predicted mouse and human amino acid sequences

Journal Article · Wed Jan 25 04:00:00 EST 1989 · Nucleic Acids Research; (UK)

DOI:https://doi.org/10.1093/nar/17.2.802· OSTI ID:5229453

Dittman, W A; Majerus, P W ^[1]

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1. Washington Univ. School of Medicine, St. Louis, MO (USA)

Thrombomodulin is an endothelial cell surface anticoagulant cofactor for activation of the serum protease protein C. The authors have previously described a complete cDNA for human thrombomodulin, and a partial cDNA for mouse thrombomodulin. They now report the complete cDNA for mouse thrombomodulin, and compare the predicted amino acid sequence to human. The sequence contains a 5{prime} untranslated region of 158 bases, followed by 1,731 bases encoding 577 amino acids, and 1,745 bases of 3{prime} untranslated sequence terminating in a poly A tail (24 bases). The sequence was determined by sequencing both strands of two independent cDNA clones, one encoding bases 1-833, the other 446-3,658.

• OSTI ID: 5229453
• Journal Information: Nucleic Acids Research; (UK), Journal Name: Nucleic Acids Research; (UK) Vol. 17:2; ISSN 0305-1048; ISSN NARHA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMAL TISSUES
ANIMALS
ANTICOAGULANTS
BIOLOGICAL EVOLUTION
BODY
DNA
DNA SEQUENCING
DRUGS
ENDOTHELIUM
ENZYMES
HEMATOLOGIC AGENTS
HYDROLASES
MAMMALS
MAN
MEMBRANE PROTEINS
MICE
MOLECULAR STRUCTURE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PRIMATES
PROTEINS
RECOMBINANT DNA
RODENTS
STRUCTURAL CHEMICAL ANALYSIS
TISSUES
VERTEBRATES