Muramyl-dipeptide and its synthetic analog as possible inducers of interleukin-2 production
Journal Article
·
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6999806
This paper studies the action of muramyl-dipeptide (MDP) and its synthetic derivative N-acetylglucosaminyl-N-acetyl-muramyl-alanyl-D-isoglutamine (GMDP) on IL2 production in a population of BALB/c mouse spleen cells. Tritium-thymidine was added to the wells in the flat-bottomed culture panes and the radioactivity of the samples was measured on a scintillation beta-counter after deposition of material was precipitated with TCA on the filters. The supernatant of the culture of activated spleen cells, stimulated by MDP or GMDP induced a proliferative response of the con A blast cells. The effectiveness of the stimulating action of MDP and GMDP, and of the classical IL2 inducer, con A, was compared.
- Research Organization:
- Academy of Medical Sciences of the USSR, Moscow
- OSTI ID:
- 6999806
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 100:8; ISSN BEXBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301* -- Cytology-- Tracer Techniques
550501 -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMIDES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CELL CULTURES
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
GLUTAMINE
GROWTH
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MICE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
REACTION KINETICS
RIBOSIDES
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
SPLEEN CELLS
STIMULATION
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
550501 -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMIDES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AZINES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CELL CULTURES
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
COUNTING TECHNIQUES
GLUTAMINE
GROWTH
HETEROCYCLIC COMPOUNDS
IMMUNE REACTIONS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
METABOLIC ACTIVATION
MICE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
PYRIMIDINES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
REACTION KINETICS
RIBOSIDES
RODENTS
SCINTILLATION COUNTING
SOMATIC CELLS
SPLEEN CELLS
STIMULATION
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES