Catabolic effects of muramyl dipeptide on rabbit chondrocytes
Journal Article
·
· Arthritis and Rheumatism; (USA)
- Kyushu Univ., Fukuoka (Japan)
Muramyl dipeptide, an essential structure for the diverse biologic activities of bacterial cell wall peptidoglycan, inhibited the synthesis of glycosaminoglycan/proteoglycan in cultured rabbit costal chondrocytes in a dose-dependent manner. Muramyl dipeptide, as well as lipopolysaccharide and interleukin-1 alpha, also enhanced the release of 35S-sulfate-prelabeled glycosaminoglycan/proteoglycan from the cell layer, which seems to reflect, at least partially, the increasing degradation of glycosaminoglycan/proteoglycan. Five synthetic analogs of muramyl dipeptide known to be adjuvant active or adjuvant inactive were tested for their potential to inhibit synthesis of glycosaminoglycan/proteoglycan and to enhance the release of glycosaminoglycan/proteoglycan in chondrocytes. The structural dependence of these synthetic analogs on chondrocytes was found to parallel that of immunoadjuvant activity. These results suggest that muramyl dipeptide is a potent mediator of catabolism in chondrocytes.
- OSTI ID:
- 5988041
- Journal Information:
- Arthritis and Rheumatism; (USA), Journal Name: Arthritis and Rheumatism; (USA) Vol. 33:12; ISSN ARHEA; ISSN 0004-3591
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARTILAGE
CATABOLISM
CELL CONSTITUENTS
CELL WALL
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
EVEN-ODD NUCLEI
GLYCOPROTEINS
GROWTH FACTORS
INHIBITION
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
LIPIDS
LIPOPOLYSACCHARIDES
LYMPHOKINES
MAMMALS
METABOLISM
MITOGENS
NUCLEI
ORGANIC COMPOUNDS
PEPTIDES
POLYSACCHARIDES
PROTEINS
RABBITS
RADIOISOTOPES
REACTION KINETICS
SACCHARIDES
SECRETION
SULFUR 35
SULFUR ISOTOPES
SYNTHESIS
TISSUES
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARTILAGE
CATABOLISM
CELL CONSTITUENTS
CELL WALL
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
EVEN-ODD NUCLEI
GLYCOPROTEINS
GROWTH FACTORS
INHIBITION
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
LIPIDS
LIPOPOLYSACCHARIDES
LYMPHOKINES
MAMMALS
METABOLISM
MITOGENS
NUCLEI
ORGANIC COMPOUNDS
PEPTIDES
POLYSACCHARIDES
PROTEINS
RABBITS
RADIOISOTOPES
REACTION KINETICS
SACCHARIDES
SECRETION
SULFUR 35
SULFUR ISOTOPES
SYNTHESIS
TISSUES
TRACER TECHNIQUES
VERTEBRATES