Radiation inactivation method provides evidence that membrane-bound mitochondrial creatine kinase is an oligomer
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Lyophilized suspensions of rabbit heart mitochondria have been irradiated with varying doses of gamma rays. Mitochondrial creatine kinase activity was inactivated exponentially with a radiation inactivation size of 352 or 377 kDa depending upon the initial medium. These values are in good agreement with the molecular mass previously deduced from by permeation experiments: 357 kDa. This is the first direct evidence showing that the native form of mitochondrial creatine kinase is associated to the inner membrane as an oligomer, very likely an octamer.
- OSTI ID:
- 6999589
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 153:3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL RADIATION EFFECTS
CHEMISTRY
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
GAMMA RADIATION
HEART
INHIBITION
IONIZING RADIATIONS
MAMMALS
MEMBRANES
MITOCHONDRIA
ORGANOIDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
RABBITS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
TRANSFERASES
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL RADIATION EFFECTS
CHEMISTRY
ELECTROMAGNETIC RADIATION
ENZYME ACTIVITY
ENZYMES
GAMMA RADIATION
HEART
INHIBITION
IONIZING RADIATIONS
MAMMALS
MEMBRANES
MITOCHONDRIA
ORGANOIDS
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
RABBITS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
TRANSFERASES
VERTEBRATES