Nodular thyroid disease in children and adolescents: a high incidence of carcinoma

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · Am. Surg.; (United States)

OSTI ID:6999415

McHenry, C; Smith, M; Lawrence, A M; Jarosz, H; Paloyan, E

Over a period of 32 years from 1954 to 1986, 65 patients under the age of 21 years, 52 girls and 13 boys, were operated for nodular thyroids: the overall incidence of carcinoma was 37 per cent. It was 46 per cent in those patients presenting with a solitary nodule. Among the 24 patients with a malignancy, the carcinoma was of the papillary variety in 63 per cent, follicular in 25 per cent and medullary in 12 per cent. Two thirds of the patients had metastatic disease at the time of presentation. All patients with thyroid carcinoma were treated with total thyroidectomy. Other measures included neck dissection and radioactive iodine. When the eight patients with a history of head and neck irradiation and the three patients with medullary carcinoma were excluded, the incidence of carcinoma was 28 per cent. In summary, in spite of the decline in radiation associated cases, the incidence of carcinoma in nodular thyroid disease in the population under 21 years, remains at the relatively high figure of 28 per cent.

• Research Organization: Loyola Univ. Medical Center, Maywood, IL (USA)
• OSTI ID: 6999415
• Journal Information: Am. Surg.; (United States), Journal Name: Am. Surg.; (United States) Vol. 54:7; ISSN AMSUA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADOLESCENTS
AGE GROUPS
BODY
CARCINOMAS
CHILDREN
DISEASES
ENDOCRINE GLANDS
GLANDS
IODINE ISOTOPES
ISOTOPES
MEDICINE
NEOPLASMS
ORGANS
PARATHYROID GLANDS
PATIENTS
RADIOINDUCTION
SURGERY
THYROID
THYROIDECTOMY