Nodular thyroid disease in children and adolescents: a high incidence of carcinoma

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Am. Surg.; (United States)

OSTI ID:6999415

McHenry, C; Smith, M; Lawrence, A M; Jarosz, H; Paloyan, E

Over a period of 32 years from 1954 to 1986, 65 patients under the age of 21 years, 52 girls and 13 boys, were operated for nodular thyroids: the overall incidence of carcinoma was 37 per cent. It was 46 per cent in those patients presenting with a solitary nodule. Among the 24 patients with a malignancy, the carcinoma was of the papillary variety in 63 per cent, follicular in 25 per cent and medullary in 12 per cent. Two thirds of the patients had metastatic disease at the time of presentation. All patients with thyroid carcinoma were treated with total thyroidectomy. Other measures included neck dissection and radioactive iodine. When the eight patients with a history of head and neck irradiation and the three patients with medullary carcinoma were excluded, the incidence of carcinoma was 28 per cent. In summary, in spite of the decline in radiation associated cases, the incidence of carcinoma in nodular thyroid disease in the population under 21 years, remains at the relatively high figure of 28 per cent.

• Research Organization: Loyola Univ. Medical Center, Maywood, IL (USA)
• OSTI ID: 6999415
• Journal Information: Am. Surg.; (United States), Vol. 54:7
• Country of Publication: United States
• Language: English

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CARCINOMAS
RADIOINDUCTION
THYROID
ADOLESCENTS
CHILDREN
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PARATHYROID GLANDS
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560151* - Radiation Effects on Animals- Man