Macrodosimetry and microdosimetry in radioimmunotherapy

Technical Report · Thu Feb 01 04:00:00 EST 1990

DOI:https://doi.org/10.2172/6998879· OSTI ID:6998879

Leichner, P. K.

This progress report summarizes the research accomplished and its clinical implementation since July 15, 1989. To improve beta-particle dosimetry, a point-source function was developed that is valid for a wide range of beta-particle emitters. An analytical solution for beta-particle dose rates within and outside of slabs of finite thickness was validated in an experimental tumor system and is now being used in clinical radioimmunotherapy (RIT). Quantitative SPECT was validated in phantom studies, beagle dogs, and patients with Kaposi's sarcoma. It is currently being used in clinical RIT for patients with Hodgkin's disease or hepatoma. Additionally, methodologies and computer software are being developed for quantitative autoradiography to achieve absorbed-dose calculation on the cellular level. 7 refs., 1 tab.

• Research Organization: Johns Hopkins Oncology Center, Baltimore, MD (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: FG02-89ER60867
• OSTI ID: 6998879
• Report Number(s): DOE/ER/60867-1; ON: DE90007366
• Country of Publication: United States
• Language: English

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