Macrodosimetry and microdosimetry in radioimmunotherapy. Final report, July 15, 1989 -- July 14, 1992

Technical Report · Sun Dec 01 04:00:00 EST 1991

DOI:https://doi.org/10.2172/145670· OSTI ID:145670

Leichner, P K

This report summarizes research in beta-particle dosimetry, quantitative single-photon emission computed tomography (SPECT), the clinical implementation of these two areas of research in radioimmunotherapy (RIT), and postgraduate training provided since the inception of this grant on July 15, 1989. To improve beta-particle dosimetry, a point source function was developed that is valid for a wide range of beta emitters. Analytical solutions for beta-particle dose rates within out outside slabs of finite thickness were validated in experimental tumors and are now being used in clinical RIT. Quantitative SPECT based on the circular harmonic transform (CHT) algorithm was validated in phantom, experimental, and clinical studies. This has led to improved macrodosimetry in clinical RIT. In dosimetry at the multi-cellular level studies were made of the HepG2 human hepatoblastoma grown subcutaneously in nude mice. Histologic sections and autoradiographs were prepared to quantitate activity distributions of radiolabeled antibodies. Absorbed-dose calculations are being carried out for {sup 131}I and {sup 90}Y beta particles for these antibody distributions.

• Research Organization: University of Nebraska Medical Center, Omaha, NE (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-91ER61195
• OSTI ID: 145670
• Report Number(s): DOE/ER/61195--1; ON: DE92006695
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ANTIBODIES
BETA PARTICLES
DOSIMETRY
FERRITIN
IODINE 131
LABELLED COMPOUNDS
NEOPLASMS
PROGRESS REPORT
RADIOIMMUNOTHERAPY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
YTTRIUM 90