Molecular cardiology: the beat goes on
Recombination DNA techniques have given cardiac physiologists their first access to the genes, proteins, and chemical signals that regulate the human heart. Scientists have been investigating the molecular biology of the angiotensinogen converting enzyme, renin, and of atrial natriuretic factor (ANF), an important cardiac-peptide hormone with a wide range of physiologic activities. Renin initiates a regulatory cascade that eventually produces angiotensin II, a potent hypertensive agent. By studying renin's genetic organization, and protein chemistry, scientists hope to be able to design a rational therapeutic to specifically inhibit this aspartyl protease. To determine if renin is endogenously produced or if it makes its way to these cells through the circulation. A combination of fluorescent-labeled antibodies and radio-labeled nucleic acid probes derived from renin cDNA were used.
- OSTI ID:
- 6998086
- Journal Information:
- Bio/Technology; (United States), Journal Name: Bio/Technology; (United States) Vol. 5:6; ISSN BTCHD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
CARDIOVASCULAR AGENTS
DRUGS
ENZYMES
GLOBULINS
HORMONES
HYDROLASES
ISOTOPE APPLICATIONS
ISOTOPES
MOLECULAR BIOLOGY
NONSPECIFIC PEPTIDASES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PEPTIDE HYDROLASES
PROTEINS
RADIOISOTOPES
RENIN
TRACER TECHNIQUES
VASOCONSTRICTORS