Teratogenicity, mutagenicity, and effects of Grade 2 diesel fuel on reproduction in a single generation of rats. Technical report, October 1979-July 1980
Technical Report
·
OSTI ID:6997525
Pregnant dams were exposed to DF-2 smoke, of tank exhaust for 1 hr and to noise from the tank's engine for 20-30 sec. One litter in the DF-2 smoke group had three fetuses with major, gross malformations and two with visceral abnormalities. The DF-2 smoke group also showed the greatest number of fetuses with sites of low bone ossification. Males in the DLM study and the males and females in the single-generation (SG) reproduction study were exposed to DF-2 smoke or exhaust for 15 or 60 min. Unexposed dams were mated to DLM males from the 15-min exhaust group during the males' second week of post-exposure. These females had significantly more resorptions than the noise controls for the same mating period. The major malformations observed in the teratology study occurred in rather isolated instances. Retarded bone ossification was indicated in the DF-2 smoke group but without significantly lower body weights. Nothing indicates that DF-2 smoke caused fetal-growth retardation. Observances in the DLM study were not strong enough to suspect a mutational effect, and the observations in the SG study gave no support for adverse effects on reproduction.
- Research Organization:
- Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD (USA)
- OSTI ID:
- 6997525
- Report Number(s):
- AD-A-189938/4/XAB; CRDEC-TR-87083
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
02 PETROLEUM
020900 -- Petroleum-- Environmental Aspects
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
COLLOIDS
DIESEL ENGINES
DIESEL FUELS
DISPERSIONS
DOCUMENT TYPES
ENGINES
EXHAUST GASES
FEMALES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INTERNAL COMBUSTION ENGINES
MALES
MAMMALS
MUTAGENS
MUTATIONS
NOISE
PETROLEUM PRODUCTS
PREGNANCY
PROGRESS REPORT
RATS
RESIDUES
RODENTS
SMOKES
SOLS
VERTEBRATES
WASTES
020900 -- Petroleum-- Environmental Aspects
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AEROSOLS
ANIMALS
BIOLOGICAL EFFECTS
COLLOIDS
DIESEL ENGINES
DIESEL FUELS
DISPERSIONS
DOCUMENT TYPES
ENGINES
EXHAUST GASES
FEMALES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INTERNAL COMBUSTION ENGINES
MALES
MAMMALS
MUTAGENS
MUTATIONS
NOISE
PETROLEUM PRODUCTS
PREGNANCY
PROGRESS REPORT
RATS
RESIDUES
RODENTS
SMOKES
SOLS
VERTEBRATES
WASTES