Influence of spironolactone and its metabolite canrenone on serum digoxin assays
Journal Article
·
· Therapeutic Drug Monitoring; (USA)
- Medical Univ. of Southern Africa, Medunsa (South Africa)
Although current immunoassay kits for digoxin supposedly have antibodies of high specificity, serum digoxin levels in patients taking spironolactone suggest that spironolactone interferes with the determination. In vitro determinations of digoxin performed on blank serum spiked with spironolactone and its metabolite canrenone showed that contrary to the belief gained from reading the manuals of some diagnostic immunoassay kits, spironolactone significantly influences digoxin determinations.
- OSTI ID:
- 6995020
- Journal Information:
- Therapeutic Drug Monitoring; (USA), Journal Name: Therapeutic Drug Monitoring; (USA) Vol. 12:1; ISSN 0163-4356; ISSN TDMOD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Spironolactone pharmacokinetics and actions in the dog: Influence on the potential spironolactone-digoxin interaction
Spironolactone-associated digoxin radioimmunoassay interference. [/sup 3/H, /sup 125/I tracer techniques]
Variability among commercially available digoxin radioimmunoassay kits in cross reactivity to dihydrodigoxin. [/sup 125/I]
Thesis/Dissertation
·
Thu Dec 31 23:00:00 EST 1987
·
OSTI ID:5547717
Spironolactone-associated digoxin radioimmunoassay interference. [/sup 3/H, /sup 125/I tracer techniques]
Journal Article
·
Sun Dec 31 23:00:00 EST 1978
· Clin. Chem.; (United States)
·
OSTI ID:6368496
Variability among commercially available digoxin radioimmunoassay kits in cross reactivity to dihydrodigoxin. [/sup 125/I]
Journal Article
·
Sat Dec 31 23:00:00 EST 1977
· Clin. Chem.; (United States)
·
OSTI ID:5734377
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL HALF-LIFE
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
DIAGNOSTIC TECHNIQUES
DIGITALIS GLYCOSIDES
DIGOXIN
DIURETICS
DRUGS
GLYCOSIDES
IMMUNOASSAY
IMMUNOLOGY
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MAN
METABOLITES
ORGANIC COMPOUNDS
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
REACTION KINETICS
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOASSAY
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL HALF-LIFE
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
DIAGNOSTIC TECHNIQUES
DIGITALIS GLYCOSIDES
DIGOXIN
DIURETICS
DRUGS
GLYCOSIDES
IMMUNOASSAY
IMMUNOLOGY
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MAN
METABOLITES
ORGANIC COMPOUNDS
PRIMATES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
REACTION KINETICS
TRACER TECHNIQUES
VERTEBRATES