Investigation of the mechanism of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated polyaromatic hydrocarbons
The toxicity of (/sup 3/H)-2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and the related halogenated polyaromatic hydrocarbons (PAHs) is presumed to be mediated by a cytosolic receptor, the Ah receptor. However, for a large number of receptor agonists, there is not strict correlation between toxicity and relative ligand binding affinity. Therefore, the possibility that the variance in toxicity was due to differences in the ability of various ligands to activate the cytosolic receptor was investigated. The five radioligands used in the study, (/sup 3/H)2,3,7,8-TCDD, (/sup 3/H)2,3,7,8-Tetrachlorodibenzofuran (TCDF), (/sup 3/H)1,2,3,7,8-Pentachlorodibenzofuran (PCDF), (/sup 3/H)1,2,3,6,7,8-Hexachlorodibenzo-furan (HCDF),and (/sup 3/H)Tetrachlorodibenzofuran-2-(TCDF-2), were of similar affinity: 0.44 nM, 1.3 nM, 5.2 nM, 2.3 nM, and 4.1 nM, respectively.
- Research Organization:
- Texas A and M Univ., College Station (USA)
- OSTI ID:
- 6991421
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CHLORINATED AROMATIC HYDROCARBONS
RECEPTORS
TOXICITY
DIOXIN
BIOCHEMICAL REACTION KINETICS
AFFINITY
LIGANDS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AROMATICS
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MEMBRANE PROTEINS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PROTEINS
REACTION KINETICS
560300* - Chemicals Metabolism & Toxicology
550201 - Biochemistry- Tracer Techniques