Investigation of the mechanism of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated polyaromatic hydrocarbons
Thesis/Dissertation
·
OSTI ID:6991421
The toxicity of (/sup 3/H)-2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and the related halogenated polyaromatic hydrocarbons (PAHs) is presumed to be mediated by a cytosolic receptor, the Ah receptor. However, for a large number of receptor agonists, there is not strict correlation between toxicity and relative ligand binding affinity. Therefore, the possibility that the variance in toxicity was due to differences in the ability of various ligands to activate the cytosolic receptor was investigated. The five radioligands used in the study, (/sup 3/H)2,3,7,8-TCDD, (/sup 3/H)2,3,7,8-Tetrachlorodibenzofuran (TCDF), (/sup 3/H)1,2,3,7,8-Pentachlorodibenzofuran (PCDF), (/sup 3/H)1,2,3,6,7,8-Hexachlorodibenzo-furan (HCDF),and (/sup 3/H)Tetrachlorodibenzofuran-2-(TCDF-2), were of similar affinity: 0.44 nM, 1.3 nM, 5.2 nM, 2.3 nM, and 4.1 nM, respectively.
- Research Organization:
- Texas A and M Univ., College Station (USA)
- OSTI ID:
- 6991421
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFFINITY
AROMATICS
BIOCHEMICAL REACTION KINETICS
CHLORINATED AROMATIC HYDROCARBONS
DIOXIN
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIGANDS
MEMBRANE PROTEINS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PROTEINS
REACTION KINETICS
RECEPTORS
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFFINITY
AROMATICS
BIOCHEMICAL REACTION KINETICS
CHLORINATED AROMATIC HYDROCARBONS
DIOXIN
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
LIGANDS
MEMBRANE PROTEINS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PROTEINS
REACTION KINETICS
RECEPTORS
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS