Gamma-irradiated scrub typhus immunogens: broad-spectrum immunity with combinations of rickettsial strains

Journal Article · Mon Oct 01 04:00:00 EDT 1979 · Infect. Immun.; (United States)

OSTI ID:6984202

Eisenberg, Jr, G H; Osterman, J V

Scrub typhus immunogens were prepared from Rickettsia tsutsugamushi strains Karp, Kato, Gilliam, Kostival, and Buie by exposing frozen infected yolk sac suspensions to 300 krad of gamma radiation. Mouse protection tests showed that each of the irradiated immunogens protected C3H/HeDub mice against high challenge levels of Karp and Gilliam, but that none of these single-strain immunogens were capable of protecting against all five of the challenge strains. Broad-spectrum protection was achieved by using combinations of three strains of irradiated rickettsiae in a vaccination regimen of three injections at 5-day intervals.

• Research Organization: Walter Reed Army Inst. of Research, Washington, DC
• OSTI ID: 6984202
• Journal Information: Infect. Immun.; (United States), Journal Name: Infect. Immun.; (United States) Vol. 26:1; ISSN INFIB
• Country of Publication: United States
• Language: English

Related Subjects

560134* -- Radiation Effects on Microorganisms-- Vaccine Preparation & Other Applications-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
COMPARATIVE EVALUATIONS
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IMMUNOLOGY
INFECTIOUS DISEASES
IONIZING RADIATIONS
MAMMALS
MICE
MICROORGANISMS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RICKETTSIAE
RICKETTSIAL DISEASES
RODENTS
TYPHUS
VACCINES
VERTEBRATES