Host defenses in experimental scrub typhus: effect of sublethal gamma radiation
Thesis/Dissertation
·
OSTI ID:5239113
The effect of sublethal gamma radiation on inbred mice chronically infected with scrub typhus rickettsiae was examined. Inbred mice which have been inoculated with Gilliam or Karp strain of Rickettsia tsutsugamushi by the subcutaneous route harbored the infection for at least one year. Irradiation of these animals at 12 or 52 weeks post inoculation at normally sublethal levels induced a significantly higher percentage of rickettsemic mice (recrudescence) than in the unirradiated similarly infected control animals. In addition, sublethal irradiation at 12 weeks also induced a quantitative increase in total rickettsiae. Homologous antibody titers to the rickettsiae were examined for five weeks following irradiation to determine the role of the humoral response in radiation induced recrudescence. Modification of recrudescence was investigated using radioprotective drugs. The expected results of this investigation supported the conclusion that the recrudescence of a chronic rickettsial infection in the appropriate host following immunological impairment due to battlefield or clinical exposure to gamma radiation can result in an acute, possibly lethal rickettsemia.
- Research Organization:
- Catholic Univ. of America, Washington, DC
- OSTI ID:
- 5239113
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550900 -- Pathology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INFECTIOUS DISEASES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIZERS
RECOVERY
RETICULOENDOTHELIAL SYSTEM
RICKETTSIAL DISEASES
RODENTS
SUBLETHAL IRRADIATION
TISSUES
TYPHUS
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INFECTIOUS DISEASES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIZERS
RECOVERY
RETICULOENDOTHELIAL SYSTEM
RICKETTSIAL DISEASES
RODENTS
SUBLETHAL IRRADIATION
TISSUES
TYPHUS
VERTEBRATES