Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effect of plasmapheresis on the liver uptake of ApoB-lipoproteins labeled with technetium-99m

Journal Article · · Artificial Organs (New York); (USA)
; ; ; ; ; ;  [1]
  1. USSR Cardiology Research Center, Moscow (USSR)
+ Show Author Affiliations

To study liver low density lipoprotein (LDL)-receptor activity before and after plasmapheresis, ({sup 99m}Tc) very low density lipoprotein (VLDL) was used. Autologous VLDL was labeled, sterilized by filtration, and administered intravenously to patients under a gamma camera. The uptake of lipoproteins in the liver was measured by scintiscanning. Liver activity curves were generated for each patient. The liver activity in patients with the heterozygous form of familial hypercholesterolemia (FH) and in patients with symptomatic atherosclerosis (SA) without hereditary deficit of LDL receptors was reduced as compared to healthy people. Plasmapheresis enhanced the liver uptake of the {sup 99m}Tc-labeled lipoproteins in atherosclerotic patients. Thus, labeled metabolites could presumably be of use in assessing the effect of plasmapheresis on liver function.

OSTI ID:
6983788
Journal Information:
Artificial Organs (New York); (USA), Journal Name: Artificial Organs (New York); (USA) Vol. 13:6; ISSN ARORD; ISSN 0160-564X
Country of Publication:
United States
Language:
English

Similar Records

Evaluation of 99mTc-LDL for studying lipoprotein metabolism and imaging atherosclerotic lesions in vivo
Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States) · OSTI ID:7030919
Stimulation of cholesteryl ester synthesis in mouse peritoneal macrophages by cholesterol-rich very low density lipoproteins from the Watanabe heritable hyperlipidemic rabbit, an animal model of familial hypercholesterolemia
Journal Article · Thu May 01 00:00:00 EDT 1986 · J. Clin. Invest.; (United States) · OSTI ID:5618299
The distribution and metabolism of Tc-/sup 99m/ labeled low density lipoprotein in human subjects
Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States) · OSTI ID:6795514

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
APOLIPOPROTEINS
ARTERIOSCLEROSIS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR DISEASES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DYNAMIC FUNCTION STUDIES
GAMMA CAMERAS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIPIDS
LIPOPROTEINS
LIVER
MATERIALS
MEMBRANE PROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RECEPTORS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
UPTAKE
VASCULAR DISEASES
YEARS LIVING RADIOISOTOPES