Comparison of rats and dogs exposed to /sup 239/PuO/sub 2/

Conference · Mon Jan 01 00:00:00 EST 1979

OSTI ID:6983609

Mahaffey, J. A.; Sanders, C. L.; Park, J. F.; Dagle, G. E.

Rats and dogs inhaled aerosols of /sup 239/PuO/sub 2/ at comparable ages relative to their lifespan. Both received a single exposure. The estimated lung doses at death in dogs were between 1100 and 11,000 rad. From two inhalation experiments, rats receiving doses in this range were chosen from the high-level exposed animals for comparison. Based on this data base, several comparisons were investigated. Metabolism of the material was compared for all animals and for animals which developed lung tumors. The differences in histopathology and tumor incidence in the lung were also reviewed. Although there were several differences between species, there were also many similarities. On-going research in dogs should produce data which will allow clarification of these relationships.

• Research Organization: Battelle Pacific Northwest Labs., Richland, WA (USA)
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6983609
• Report Number(s): PNL-SA-8091; CONF-791077-6; TRN: 81-003309
• Resource Relation: Conference: Workshop on measurement and interpretation of actinide accumulation by man, Snowbird, UT, USA, 14 Oct 1979
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DOGS
NEOPLASMS
SURVIVAL TIME
PLUTONIUM DIOXIDE
BIOLOGICAL RADIATION EFFECTS
RATS
ACUTE EXPOSURE
AGE DEPENDENCE
BIOLOGICAL HALF-LIFE
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
HISTOLOGY
INHALATION
LETHAL IRRADIATION
LUNGS
PATHOLOGICAL CHANGES
PLUTONIUM 239
RADIATION DOSES
RADIONUCLIDE KINETICS
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DATA
DISEASES
DOSES
EVEN-ODD NUCLEI
HEAVY NUCLEI
INFORMATION
INTAKE
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION EFFECTS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
TRANSURANIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells