Asbestos body formation and iron accumulation in mouse peritoneal granulomas after the introduction of crocidolite asbestos fibers
- Univ. of Leiden (Netherlands)
This report describes the cell biology of the development of asbestos bodies after a single intraperitoneal injection of a suspension of crocidolite asbestos fibers into the mouse peritoneal cavity. The majority of the infected fibers were found in aggregates of peritoneal macrophages, exudate cells, and fibrous tissue. These aggregates developed into granulomas containing not only numerous asbestos fibers, but also cells of various types, including macrophages, multinucleated giant cells, fibroblasts, plasma cells, granulocytes, and mast cells. Cytoplasmic ferritin was abundantly present in macrophages and giant cells. In addition, iron-rich inclusion bodies were detected. The results of this study show that asbestos body formation can occur outside the pleural cavity. Asbestos body formation occurred in the granulomas after periods of 1 month and longer. On the basis of morphologic criteria, various types of asbestos body were distinguished. X-ray microanalysis showed that variations in the density of the coat could attributed to the presence of chemical elements in various concentrations. Evidence is presented that asbestos body formation is an extracellular phenomenon.
- OSTI ID:
- 6982865
- Journal Information:
- American Journal of Pathology; (USA), Vol. 136:1; ISSN 0002-9440
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ASBESTOS
TOXICITY
IRON
BIOLOGICAL ACCUMULATION
PERITONEUM
GRANULOMAS
CYTOPLASM
ELECTRON MICROPROBE ANALYSIS
FIBROBLASTS
INTRAPERITONEAL INJECTION
MACROPHAGES
MAST CELLS
MICE
ANIMAL CELLS
ANIMALS
CELL CONSTITUENTS
CHEMICAL ANALYSIS
CONNECTIVE TISSUE CELLS
DISEASES
ELEMENTS
INJECTION
INTAKE
MAMMALS
MEMBRANES
METALS
MICROANALYSIS
NEOPLASMS
PHAGOCYTES
RODENTS
SEROUS MEMBRANES
SOMATIC CELLS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550602 - Medicine- External Radiation in Diagnostics- (1980-)