DNA polymorphism of alkaline phosphatase isozyme genes: Linkage disequilibria between placental and germ-cell alkaline phosphotase alleles
Journal Article
·
· American Journal of Human Genetics; (United States)
OSTI ID:6975596
- Univ. of Umea (Sweden)
- La Jolla Cancer Research Foundation, CA (United States)
The use of human placental alkaline phosphatase (PLAP) cDNA as a probe allows the detection and identification of restriction DNA fragments derived from three homologous genes, i.e., intestinal alkaline phosphatase (AP), germ-cell AP (GCAP), and PLAP. In previous RFLP studies the authors have reported linkage disequilibria between an RsaI and two PstI (a and b) polymorphic restriction sites and electrophoretic types of PLAP. In this report they present evidence that, in spite of the strong correlation with PLAP types, PstI(b) is an RFLP of GCAP. The data indicate close linkage between the PLAP and GCAP loci. 18 refs., 2 figs., 3 tabs.
- OSTI ID:
- 6975596
- Journal Information:
- American Journal of Human Genetics; (United States), Journal Name: American Journal of Human Genetics; (United States) Vol. 51:5; ISSN AJHGAG; ISSN 0002-9297
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pst I restriction fragment length polymorphism of human placental alkaline phosphatase gene: Mendelian in segregation and localization of mutation site in the gene
Cloning and sequencing of human intestinal alkaline phosphatase cDNA
Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase
Journal Article
·
Sat Oct 01 00:00:00 EDT 1988
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:5546634
Cloning and sequencing of human intestinal alkaline phosphatase cDNA
Journal Article
·
Sat Jan 31 23:00:00 EST 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6372767
Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase
Journal Article
·
Sat Feb 28 23:00:00 EST 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:6179285