Comparison of iohexol with metrizamide in myelography

Journal Article · Sun Apr 01 04:00:00 EST 1984 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.151.1.6701301· OSTI ID:6973888

Sortland, O; Nestvold, K; Kloster, R; Aandahl, M H

Myelography of the lumbar and lower thoracic spine was performed in 46 patients (23 using metrizamide and 23 using iohexol) as a parallel double blind randomized study. Neurological examinations, laboratory testing, and EEG studies were performed before and after myelography, and side effects were recorded. On comparison, adverse reactions were observed in a statistically significant lower number of patients when iohexol was used. The frequency and duration of each single adverse reaction was also lower following use of iohexol, but this was not statistically significant. Three patients had severe reactions following use of metrizamide, and in one patient sharp waves were recorded on EEG. No severe reactions, no mental reactions, and no muscular symptoms were seen following use of iohexol, and the authors consider this contrast medium better tolerated in the subarachnoid space than metrizamide.

• Research Organization: Univ. of Oslo, Nordbyhagen Norway
• OSTI ID: 6973888
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 151:1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMIDES
BIOMEDICAL RADIOGRAPHY
BLOOD PRESSURE
BODY
COMPARATIVE EVALUATIONS
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
IOHEXOL
MEDICINE
METRIZAMIDE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
RADIOLOGY
SIDE EFFECTS
SKELETON
VERTEBRAE