Lumbar myelography with iohexol and metrizamide: a comparative multicenter prospective study

Conference · Fri Jun 01 04:00:00 EDT 1984 · Radiology; (United States)

OSTI ID:6581357

Kieffer, S A; Binet, E F; Davis, D O; Gabrielsen, T O; Kido, D K; Latchaw, R E; Turski, P A; Shaw, D D

Diagnostic quality of radiographs and adverse reactions associated with the use of metrizamide and iohexol as contrast agents in lumbar myelography were compared in a prospective randomized double blind study in 350 patients at seven centers. Overall quality of radiographic visualization was graded good or excellent in 95% of 175 metrizamide studies and in 98% of 175 iohexol studies. Ninety-three patients examined using metrizamide (53%) and 130 patients examined using iohexol (74%) experienced no discomfort during or after myelography. Postmyelographic headache was associated with 38% of metrizamide examinations and 21% of iohexol examinations. Nausea and vomiting were also more common with metrizamide. Five patients examined using metrizamide (3%) experienced transient confusion and disorientation following lumbar myelography. No such reactions were observed following iohexol myelography.

• Research Organization: State Univ. of New York Upstate Medical Center, Syracuse
• OSTI ID: 6581357
• Report Number(s): CONF-8311191-
• Conference Information: Journal Name: Radiology; (United States) Journal Volume: 151:3
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMIDES
BIOMEDICAL RADIOGRAPHY
CENTRAL NERVOUS SYSTEM
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
IOHEXOL
MEDICINE
METRIZAMIDE
NAUSEA
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
RADIOLOGY
SIDE EFFECTS
SPINAL CORD
SYMPTOMS
VOMITING