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Uptake and distribution of /sup 14/C during and following exposure to (/sup 14/C)methyl isocyanate

Journal Article · · Toxicol. Appl. Pharmacol.; (United States)
; ; ; ;

Guinea pigs were exposed to (/sup 14/C)methyl isocyanate (/sup 14/CH/sub 3/-NCO, /sup 14/C MIC) for periods of 1 to 6 hr at concentrations of 0.5 to 15 ppm. Arterial blood samples taken during exposure revealed immediate and rapid uptake of /sup 14/C. Clearance of /sup 14/C was then gradual over a period of 3 days. Similarly /sup 14/C was present in urine and bile immediately following exposure, and clearance paralleled that observed in blood. Guinea pigs fitted with a tracheal cannula and exposed while under anesthesia showed a reduced /sup 14/C uptake in blood indicating that most of the /sup 14/C MIC uptake in normal guinea pigs occurred from retention of this agent in the upper respiratory tract passages. In exposed guinea pigs /sup 14/C was distributed to all examined tissues. In pregnant female mice similarly exposed to /sup 14/C MIC, /sup 14/C was observed in all tissues examined following exposure including the uterus, placenta, and fetus. While the form of /sup 14/C distributed in blood and tissues has not yet been identified, these findings may help to explain the toxicity of MIC or MIC reaction products on organs other than the respiratory tract, as noted by several investigators.

Research Organization:
Univ. of Pittsburgh, Pennsylvania (USA)
OSTI ID:
6970990
Journal Information:
Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 94:1; ISSN TXAPA
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BILE
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CLEARANCE
CYANATES
DISTRIBUTION
DRUGS
GLUTATHIONE
GUINEA PIGS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
VERTEBRATES