Toxicity of inhaled methyl isocyanate vapor
Thesis/Dissertation
·
OSTI ID:5542304
The toxicity of inhaled isocyanate (MIC) vapor was evaluated using several bioassays designed to investigate the toxicity of airborne chemicals. Two methods which measure changes in respiratory rate and identify characteristic breathing patterns in mice were used to evaluate the potency of MIC as a sensory and pulmonary irritant. Using the CO{sub 2} challenge method in conjunction with the measurement of airflow (V) and tidal volume (VT), the pulmonary effects and subsequent recovery process following a single exposure to MIC were studied in guinea pigs for a period of one year. Flow-volume loops were also obtained by plotting V vs. VT. Measurement of O{sub 2} uptake and CO{sub 2} output were also performed to determine the acute and chronic effects of MIC exposure on gas exchange. Lastly, guinea pigs and mice were exposed to {sup 14}C-MIC in an effort to determine uptake and fate of inhaled MIC.
- Research Organization:
- Pittsburgh Univ., PA (USA)
- OSTI ID:
- 5542304
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CARBON 14 COMPOUNDS
FLUIDS
GASES
GUINEA PIGS
INHALATION
INTAKE
ISOCYANATES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MICE
RESPIRATION
RODENTS
TOXICITY
TRACER TECHNIQUES
VAPORS
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CARBON 14 COMPOUNDS
FLUIDS
GASES
GUINEA PIGS
INHALATION
INTAKE
ISOCYANATES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
MICE
RESPIRATION
RODENTS
TOXICITY
TRACER TECHNIQUES
VAPORS
VERTEBRATES