Resorcinol: Final goitrogenic product in water from a goitrogenic well

Journal Article · Thu Dec 31 23:00:00 EST 1987 · [Formerly used by DOE/TIC for titles for which valid CODEN was not available. Now invalid] 92-DEC-15; (Country unknown/Code not available)

OSTI ID:6969353

Gaitan, E; Cooksey, R C ^[1]; Jolley, R L ^[2]; Lindsay, R H; Hill, J B ^[3]; Island, D P ^[4]

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1. Univ. of Mississippi, Jackson (United States) Veterans Administration Medical Center, Jackson, MS (United States)
2. Oak Ridge National Lab., TN (United States)
3. University of Alabama, Birmingham (United States) Veterans Administration Medical Center, Birmingham (United States)
4. Vanderbilt Univ., Nashville, TN (United States)

In Candelaria, Colombia, SA, goiter prevalence among children was 23% in Zone A and 11% in Zone B (p <0.05). Socioeconomic conditions, dietary composition or iodine intake could not explain this difference. However, the water for the town was supplied by two wells through independent pipeline systems, one located in Zone A and the other in Zone B. Within a year, the goiter prevalence rose to 31% in Zone B, while that in Zone A remained the same, 26% (p,NS). This indicated that water from well A might contain goitrogens. Rats drinking water or activated carbon extracts from well A developed larger thyroid glands and more pronounced thiourea-like antithyroid effects than rats drinking water or extracts from well B. Similar results were obtained by the acute in vivo suppression of thyroid 131I-uptake in mice and by in vitro assays, Elemental analysis and infrared spectrometry of well A goitrogenic water extracts (GWE) gave composition and common absorption bands similar to those of aquatic humic substances (HS). The HS, fulvic and humic acids, inhibited thyroid peroxidase (TPO) in vitro with 15% of the potency of propylthiouracil (PTU). GC/MS analysis of GWE identified over 30 organic compounds, including resorcinol. In contrast only four compounds, not including resorcinol, were identified in well B non-GWE. Resorcinol was goitrogenic and antithyroid in two different rat strains.

• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6969353
• Journal Information: [Formerly used by DOE/TIC for titles for which valid CODEN was not available. Now invalid] 92-DEC-15; (Country unknown/Code not available), Journal Name: [Formerly used by DOE/TIC for titles for which valid CODEN was not available. Now invalid] 92-DEC-15; (Country unknown/Code not available) Vol. 5:4; ISSN ZZZZZV
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540320* -- Environment
Aquatic-- Chemicals Monitoring &amp; Transport-- (1990-)
560300 -- Chemicals Metabolism &amp; Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMALS
AROMATICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHILDREN
CHROMATOGRAPHY
CONTAMINATION
DAYS LIVING RADIOISOTOPES
DEVELOPERS
DISEASES
DRINKING WATER
ENDOCRINE DISEASES
ENDOCRINE GLANDS
ENZYMES
EPIDEMIOLOGY
FULVIC ACIDS
GAS CHROMATOGRAPHY
GLANDS
GOITER
HUMIC ACIDS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INSTITUTIONAL FACTORS
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LATIN AMERICA
MAMMALS
MASS SPECTROSCOPY
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEROXIDASES
PHENOLS
POLLUTION
POLYPHENOLS
PROTEINS
RADIOISOTOPES
RATS
RESORCINOL
RODENTS
SEPARATION PROCESSES
SOCIO-ECONOMIC FACTORS
SOUTH AMERICA
SPECTROSCOPY
THYROID
TOXICITY
TRACER TECHNIQUES
VERTEBRATES
WATER
WATER POLLUTION