Resorcinol: Final goitrogenic product in water from a goitrogenic well
In Candelaria town of Columbia, SA, goiter prevalence among children was 23% in Zone B (p<0.05). Socioeconomic conditions, dietary composition, or iodine intake could not explain this difference. Water for the town was supplied by two wells through independent pipeline systems, one located in Zone A and the other in Zone B. Waters from these two wells were combined in a single tank and the whole town was supplied through a common pipeline system. Within a year, goiter prevalence rose to 31% in Zone b, while that in Zone A remained the same, 26% (p,NS). Rats drinking water or activated carbon extracts from Well A developed larger thyroid glands and more pronounced thiourea-like antithyroid effects than rats drinking water or extracts from Well B. Similar results were obtained by the acute in vivo suppression of thyroid /sup 131/I-uptake in mice and by two in vitro assays. Elemental analysis and infrared spectromentery of Well A goitrogenic water extracts (GWE) gave similar compositon and common absorption bands to those of aquatic humic substances (HS). The HS, fulvic and humic acids, inhibited thyroid peroxidase (TPO) in vitro with 15% of the potency of propylthiouracil (PTU). GCMS analsysis of GWE identified over 30 organic compounds, including resorcinol. Resorcinol was goitrogenic and antithyroid in 2 different rat strains. Resorcinol appeared to be a final goitrogenic by-product of shale-derived HS contaminating water of the goitrogenic well of Candelaria. 46 refs., 3 figs., 4 tabs
- Research Organization:
- Mississippi Univ., Jackson (USA). Medical School; Oak Ridge National Lab., TN (USA); Alabama Univ., Birmingham (USA). Medical School; Vanderbilt Univ., Nashville, TN (USA). Medical School
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5201612
- Report Number(s):
- CONF-880262-1; ON: DE88007471
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Aquatic-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900* -- Pathology
552000 -- Public Health
59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS
ACTIVATED CARBON
ADSORBENTS
ADSORPTION
ANIMALS
AROMATICS
CARBON
CARBOXYLIC ACID SALTS
CHEMICAL COMPOSITION
CHEMICAL REACTIONS
CHROMATOGRAPHY
COAL LIQUEFACTION
COLOMBIA
CONTAMINATION
DATA
DECOMPOSITION
DEVELOPERS
DISEASE INCIDENCE
DISEASES
DISTILLATION
ELEMENTS
ENDOCRINE DISEASES
ENZYME INHIBITORS
ENZYMES
EPIDEMIOLOGY
ETIOLOGY
EXPERIMENTAL DATA
FULVIC ACIDS
GAS CHROMATOGRAPHY
GOITER
HALOGEN COMPOUNDS
HALOGENS
HAZARDS
HEALTH HAZARDS
HORMONES
HUMAN POPULATIONS
HUMIC ACIDS
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
IN VIVO
INFORMATION
INFRARED SPECTRA
IODINE
ION EXCHANGE CHROMATOGRAPHY
LATIN AMERICA
LIQUEFACTION
LIQUID COLUMN CHROMATOGRAPHY
LIQUID WASTES
MAMMALS
MASS SPECTROMETERS
MEASURING INSTRUMENTS
MICROANALYSIS
MOLECULAR WEIGHT
NONMETALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEPTIDE HORMONES
PEROXIDASES
PHENOLS
PHTHALATES
POLYPHENOLS
POPULATIONS
RATS
REDUCING AGENTS
RESORCINOL
ROCKS
RODENTS
SEDIMENTARY ROCKS
SEPARATION PROCESSES
SHALES
SORPTION
SOUTH AMERICA
SPECTRA
SPECTROMETERS
SULFUR
THERMOCHEMICAL PROCESSES
THIN-LAYER CHROMATOGRAPHY
THYROID HORMONES
VERTEBRATES
WASTES
WATER
WATER WELLS
WELLS