Effect of exposure route, regimen, and duration on benzene-induced genotoxic and cytotoxic bone marrow damage in mice
- Brookhaven National Laboratory, Upton, NY (USA)
Mice were exposed to benzene for 13 to 14 weeks by inhalation for either 3 or 5 consecutive days per week or by gavage for 5 consecutive days per week. A weekly evaluation of peripheral blood smears for micronucleated (MN) erythrocyte frequencies and for the percentage of polychromatic erythrocytes (PCE) indicated that the induction of MN-PCE by benzene depended on the sex and strain of mice and on the route of exposure, but not on the inhalation regimen or on the exposure duration. The frequency of MN normochromatic erythrocytes (NCE) not only depended on the sex and strain of mice and on the route of exposure, but directly depended on the inhalation regimen and on the exposure duration. Similarly, the extent of erythropoietic depression in benzene-exposed mice was dependent on sex, mouse strain, exposure duration, and route. However, in contrast to the MN-NCE data, the 3 day/week exposure regimen induced a more persistent depression in erythropoiesis than the 5 day/week exposure regimen. Exposure to benzene also induced in mice a significant depression in packed cell volume (PCV) and bone marrow cellularity, the magnitude of which depended on the sex and strain of mice and on the regimen and route of exposure.
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6967902
- Journal Information:
- Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 82; ISSN 0091-6765; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
CYTOLOGY
ERYTHROCYTES
HYDROCARBONS
INHALATION
INTAKE
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
RODENTS
SEX DEPENDENCE
SOMATIC CELLS
TIME DEPENDENCE
TOXICITY
VERTEBRATES