Long-term carcinogenicity study in Syrian golden hamster of particulate emissions from coal- and oil-fired power plants
Male Syrian golden hamsters were given 15 weekly intratracheal instillations with suspensions of coal fly ash or oil fly ash. Controls were instilled with saline containing gelatine (0.5 g/100 mL) or to check particle effects with suspensions of hematite (Fe/sub 2/O/sub 3/). The common weekly dose was 4.5 mg/hamster. In addition, one subgroup of hamsters was treated with oil fly ash at a weekly dose of 3.0 mg/hamster and another with coal fly ash at a weekly dose of 6.0 mg/hamster. Other groups of hamsters were treated with suspensions of benzo(a)pyrene (BaP) or with suspensions on coal fly ash, oil fly ash, or Fe/sub 2/O/sub 3/ coated with BaP. The mass median aerodynamic diameters of the coal and oil fly ashes were 4.4 microns and 28 microns, respectively. Hamsters treated with oil fly ash showed a higher frequency of bronchiolar-alveolar hyperplasia than hamsters in the other treatment groups. Squamous dysplasia and squamous metaplasia were most frequent in animals treated with suspensions of BaP or BaP-coated particles. The earliest appearance of a tumor, the highest incidence of tumors, and the highest incidence of malignant tumors were observed in hamsters treated with oil fly ash coated with BaP. Squamous cell carcinoma and adenosquamous carcinoma were the most frequent malignant tumors. No malignant tumors and only few benign tumors were observed in hamsters instilled with suspensions of fly ash not coated with BaP. The present study gives no indication that coal fly ash could create more serious health problems than oil fly ash.
- Research Organization:
- National Defence Research Institute, Umea (Sweden)
- OSTI ID:
- 6964977
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 77; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
BENZOPYRENE
BIOLOGICAL MODELS
CARBON
CARBONACEOUS MATERIALS
CARCINOGENESIS
CARCINOMAS
CHALCOGENIDES
COAL
CONDENSED AROMATICS
DISEASE INCIDENCE
DISEASES
ELEMENTS
ENERGY SOURCES
FLY ASH
FOSSIL FUELS
FOSSIL-FUEL POWER PLANTS
FUELS
HAMSTERS
HEMATITE
HYDROCARBONS
IRON COMPOUNDS
IRON ORES
IRON OXIDES
MAMMALS
MATERIALS
MINERALS
NEOPLASMS
NONMETALS
OILS
ORES
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PARTICLE SIZE
PARTICLES
PARTICULATES
PATHOGENESIS
PETROLEUM
POWER PLANTS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SIZE
THERMAL POWER PLANTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
WASTES