Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

The graft-versus-host reaction and immune function. I. T helper cell immunodeficiency associated with graft-versus-host-induced thymic epithelial cell damage

Journal Article · · Transplantation; (United States)
OSTI ID:6963565
; ;

The injection of parental A strain lymphoid cells into adrenalectomized CBAxA F1 (BAF1) mice induced a chronic graft-versus-host (GVH) reaction resulting in T cell and B cell immunosuppression as well as thymic epithelial cell injury, but not stress-related thymic involution. Thymocytes from BAF1 mice undergoing a GVH reaction were studied for their ability to reconstitute T helper cell (TH) function and phytohemagglutinin (PHA) and concanavalin A (Con A) mitogen responses in thymectomized, irradiated, BAF1 mice reconstituted with normal syngeneic bone marrow (ATxBM). Thymocytes from BAF1 mice early after the induction of a GVH reaction (days 10-12) were as effective as normal thymocytes in reconstituting TH and mitogen responses. Thymocytes from BAF1 mice 40 or more days after the induction of a GVH reaction did not reconstitute either the TH function or PHA and Con A responses in ATxBM mice. The inability to reconstitute ATxBM mice was not due to the presence of suppressor cells contained in the thymocyte inoculum. It is proposed that GVH-induced thymic epithelial cell injury blocks or arrests normal T cell differentiation, resulting in a population of thymocytes that lack the potential to become competent T helper cells or mitogen-responsive cells when transferred into ATxBM mice. This thymic functional defect results in a permanent TH immunodeficiency in mice experiencing a chronic GVH reaction.

Research Organization:
Department of Physiology, McGill University, Montreal, Quebec, Canada
OSTI ID:
6963565
Journal Information:
Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 37:3; ISSN TRPLA
Country of Publication:
United States
Language:
English

Similar Records

Graft-versus-host reaction and immune function. III. Functional pre-T cells in the bone marrow of graft-versus-host-reactive mice displaying T cell immunodeficiency
Journal Article · Fri Jan 31 23:00:00 EST 1986 · Transplantation; (United States) · OSTI ID:5859455
The graft-versus-host reaction and immune function. II. Recruitment of pre-T-cells in vivo by graft-versus-host-induced dysplastic thymuses following irradiation and bone marrow treatment
Journal Article · Wed Feb 29 23:00:00 EST 1984 · Transplantation; (United States) · OSTI ID:6963559
Graft-versus-host reaction and immune function. IV. B cell functional defect associated with a depletion of splenic colony-forming units in marrow of graft-versus-host-reactive mice
Journal Article · Fri Jan 31 23:00:00 EST 1986 · Transplantation; (United States) · OSTI ID:5633011

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGGLUTININS
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
CARBOHYDRATES
CHIMERAS
CONNECTIVE TISSUE CELLS
GRAFT-HOST REACTION
HEMAGGLUTININS
IMMUNE REACTIONS
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MEDICINE
MICE
MITOGENS
MOSAICISM
MUCOPROTEINS
ORGANIC COMPOUNDS
ORGANS
PHYTOHEMAGGLUTININ
POLYSACCHARIDES
PROTEINS
RADIATION EFFECTS
RODENTS
SACCHARIDES
SOMATIC CELLS
SURGERY
THYMECTOMY
THYMOCYTES
THYMUS
TRANSPLANTS
VERTEBRATES