Control of hapten specific contact sensitivity and cytotoxic T cells by orally administered hapten
Oral administration of the hapten trinitrochlorobenzene (TNCB) generates an efferently acting suppressor T cell (Ts eff) and an intermediary T acceptor cell (T acc) that together down-regulate contact sensitivity to TNCB. The production of Ts eff in mice fed TNCB was established by its specificity for the hapten, insensitivity to pretreatment with cyclophosphamide (CY), ability to produce soluble suppressor factor (SSF) and requirement to interact with T acc to be functional. T acc, on the other hand, was confirmed by its sensitivity to CY, interaction with Ts eff or SSF, and the ability (when armed with SSF and triggered appropriately with the hapten) to produce nonspecific inhibitor of immune T cells that transfer CS. Intragastric administration of TNCB also caused suppression of development of hapten specific cytotoxic T lymphocytes (CTLs) in vivo. Furthermore, spleen cells of hapten fed mice when sensitized in vitro, showed suppressed CTL responses. Presently, they seek to determine whether suppression of development of hapten specific CTLs is attributable to interaction between Ts eff and T acc cells that have been shown to arise in hapten fed mice.
- Research Organization:
- Cleveland Clinic Foundation, OH
- OSTI ID:
- 6962201
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:4; ISSN FEPRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHEMICAL ACTIVATION
CONNECTIVE TISSUE CELLS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NITRO COMPOUNDS
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
SENSITIVITY
SOMATIC CELLS
SPLEEN CELLS
VERTEBRATES