Analysis of the mechanisms by which amphetamine releases dopamine from striatal dopaminergic neurons
Thesis/Dissertation
·
OSTI ID:6956670
The goals of the studies were (1) to determine the intraneuronal transmitter pools that contribute to the efflux of dopamine (DA) elicited by amphetamine (AMPH) and (2) to determine the biochemical mechanism by which AMPH increases DA efflux from dopaminergic neurons. AMPH increased the efflux of endogenous DA and decreased the electrically-evoked overflow of (/sup 3/H) acetylcholine (ACh) from superfused rabbit striatal slices. These effects were most pronounced when both vesicular DA stores and DA synthesis were intact. Therefore, extravesicular, newly synthesized DA and vesicular stores of DA contribute to AMPH-induced DA efflux. Simultaneous inhibition of monoamine oxidase (MAO) and neuronal DA uptake did not increase the efflux of endogenous DA or inhibit the electrically-evoked overflow of (/sup 3/H)ACh to the same extent as AMPH. Hence, inhibition of MAO and neuronal DA uptake are probably not the major mechanisms by which AMPH increases DA efflux. The AMPH-induced efflux of endogenous or (/sup 3/H)DA was blocked by inhibitors of neuronal DA uptake.
- Research Organization:
- North Carolina Univ., Chapel Hill (USA)
- OSTI ID:
- 6956670
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
AMINE OXIDASES
AMINES
AMMONIUM COMPOUNDS
AMPHETAMINES
ANALEPTICS
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
DOPAMINE
DRUGS
ENZYMES
ESTERS
HYDROXY COMPOUNDS
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE TRANSPORT
NERVE CELLS
NEUROREGULATORS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PARASYMPATHOMIMETICS
PHENOLS
POLYPHENOLS
QUATERNARY COMPOUNDS
RABBITS
REACTION KINETICS
SOMATIC CELLS
SYMPATHOMIMETICS
SYNTHESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
AMINE OXIDASES
AMINES
AMMONIUM COMPOUNDS
AMPHETAMINES
ANALEPTICS
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOSYNTHESIS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
DOPAMINE
DRUGS
ENZYMES
ESTERS
HYDROXY COMPOUNDS
INHIBITION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE TRANSPORT
NERVE CELLS
NEUROREGULATORS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PARASYMPATHOMIMETICS
PHENOLS
POLYPHENOLS
QUATERNARY COMPOUNDS
RABBITS
REACTION KINETICS
SOMATIC CELLS
SYMPATHOMIMETICS
SYNTHESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES