Assessing the risks to young children of three effects associated with elevated blood-lead levels

Technical Report · Sun Nov 30 23:00:00 EST 1986

OSTI ID:6956462

Wallsten, T S; Whitfield, R G

Formal risk assessments were conducted as part of the US Environmental Protection Agency's current review of the primary National Ambient Air Quality Standard for lead. The assessments focused on three potentially adverse effects of exposure to lead in children from birth through the seventh birthday: erythrocyte protoporphyrin (EP) elevation, hemoglobin (Hb) decrement, and intelligence quotient (IQ) effect. The same general strategy was followed in all three cases: for two levels of each effect, probability distributions over population response rate were estimated at a series of blood-lead (PbB) levels. These distributions were estimated from data in the case of EP elevation and from expert judgements in the cases of Hb decrement and IQ effect. Although of interest in their own right, these estimates were combined with PbB distributions to yield probability distributions over the estimated percentages of children experiencing the particular health effects. 15 refs., 24 figs., 24 tabs.

• Research Organization: Argonne National Lab., IL (USA)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 6956462
• Report Number(s): ANL/AA-32; ON: DE87004219
• Country of Publication: United States
• Language: English

Related Subjects

550100 -- Behavioral Biology
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BEHAVIOR
BLOOD CHEMISTRY
CARBOXYLIC ACIDS
CHILDREN
DATA
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EPIDEMIOLOGY
EXPERIMENTAL DATA
GLOBIN
HAZARDS
HEALTH HAZARDS
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INFANTS
INFORMATION
LEAD
METALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RISK ASSESSMENT
STATISTICAL DATA