Radioimmunotherapy with alpha-particle-emitting immunoconjugates
Journal Article
·
· Science (Washington, D.C.); (United States)
Alpha particles are energetic short-range ions whose higher linear energy transfer produces extreme cytotoxicity. An ..cap alpha..-particle-emitting radioimmunoconjugate consisting of a bismuth-212-labeled monoclonal immunoglobulin M specific for the murine T cell/neuroectodermal surface antigen Thy 1.2 was prepared. Analysis in vitro showed that the radioimmunoconjugate was selectively cytotoxic to a Thy 1.2/sup +/ EL-4 murine tumor cell line. Approximately three bismuth-212-labeled immunoconjugates per target cell reduced the uptake of (/sup 3/H)thymidine by the EL-4 target cells to background levels. Mice inoculated intraperitoneally with EL-4 cells were cured of their ascites after intraperitoneal injection of 150 microcuries of the antigen-specific radioimmunoconjugate, suggesting a possible role for such conjugates in intracavitary cancer therapy. 18 references, 3 figures.
- Research Organization:
- Harvard Medical School, Boston, MA (USA)
- DOE Contract Number:
- FG02-86ER60460; W-31109-ENG-38
- OSTI ID:
- 6954800
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 240; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMALS
ANTIBODIES
ASCITES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH 212
BISMUTH ISOTOPES
CHARGED PARTICLES
GLOBULINS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOGLOBULINS
IMMUNOLOGY
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MICE
MONOCLONAL ANTIBODIES
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SYMPTOMS
THERAPY
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALPHA DECAY RADIOISOTOPES
ALPHA PARTICLES
ANIMALS
ANTIBODIES
ASCITES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH 212
BISMUTH ISOTOPES
CHARGED PARTICLES
GLOBULINS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOGLOBULINS
IMMUNOLOGY
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MICE
MONOCLONAL ANTIBODIES
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
SYMPTOMS
THERAPY
VERTEBRATES