Effects of hydroxymethanesulfonate on airway function in subjects with asthma. Final report
Technical Report
·
OSTI ID:6946946
The organic ion hydroxymethanesulfonate (HMSA) has been measured in micro-molecular concentrations in acidic fogs in southern California. HMSA is a stable adduct in fogs with a pH range of 3-5, but it is likely to dissociate at pH 6.6, the pH of the human airways fluid lining. It was hypothesized that HMSA may have a specific bronchoconstrictor effect because HMSA may dissociate in the airway lumen generating SO{sub 2} and CH{sub 2}O, both of which have bronchoconstrictor potential. In order to determine whether HMSA has such an effect, a total of 19 subjects with mild to moderate asthma were studied in an exposure chamber in which freely breathing and exercising subjects inhaled simulated fogs containing HMSA at a concentration (1000 micro M) higher than the ambient levels for 1 hour. The results indicated no significant bronchoconstrictor effect for acute exposures of HMSA.
- Research Organization:
- California Univ., San Francisco, CA (USA). Lung Biology Center
- OSTI ID:
- 6946946
- Report Number(s):
- PB-90-164542/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
540120* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID RAIN
AIR POLLUTION
ANIMALS
ASTHMA
ATMOSPHERIC PRECIPITATIONS
BIOLOGICAL EFFECTS
BODY
CALIFORNIA
DISEASES
DOCUMENT TYPES
EXPOSURE CHAMBERS
FEDERAL REGION IX
FOG
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
NORTH AMERICA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PH VALUE
POLLUTION
PRIMATES
PROGRESS REPORT
RAIN
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SIMULATION
USA
VERTEBRATES
540120* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID RAIN
AIR POLLUTION
ANIMALS
ASTHMA
ATMOSPHERIC PRECIPITATIONS
BIOLOGICAL EFFECTS
BODY
CALIFORNIA
DISEASES
DOCUMENT TYPES
EXPOSURE CHAMBERS
FEDERAL REGION IX
FOG
INHALATION
INTAKE
LUNGS
MAMMALS
MAN
NORTH AMERICA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PH VALUE
POLLUTION
PRIMATES
PROGRESS REPORT
RAIN
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SIMULATION
USA
VERTEBRATES