Lack of bronchomotor response to up to 3 ppm formaldehyde in subjects with asthma
Journal Article
·
· Environ. Res.; (United States)
A study was undertaken to determine whether exposure to concentrations of formaldehyde occasionally encountered in polluted indoor air would cause bronchoconstriction in subjects with mild asthma. In seven subjects the increase in specific airways resistance (SR/sub aw/) caused by inhalation of 1 ppm formaldehyde for 10 min was compared with the response caused by inhalation of formaldehyde-free air. Also, the increase in SR/sub aw/ caused by inhalation of 1 and 3 ppm formaldehyde during moderate exercise for 10 min was compared with the response caused by inhalation of formaldehyde-free air during exercise for 10 min. Inhalation of formaldehyde at rest and during exercise did not cause a signficant increase in SR/aw/ in the subjects. It is concluded that brief exposure to these concentrations of formaldehyde, even in association with moderate exercise, is unlikely by itself to cause significant bronchoconstriction in most subjects with mild asthma.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6016723
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 35:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALDEHYDES
ASTHMA
BIOLOGICAL EFFECTS
BODY
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
ENVIRONMENTAL EXPOSURE PATHWAY
EXERCISE
EXPERIMENTAL DATA
FORMALDEHYDE
INDOOR AIR POLLUTION
INFORMATION
INHALATION
INTAKE
LUNGS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALDEHYDES
ASTHMA
BIOLOGICAL EFFECTS
BODY
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
ENVIRONMENTAL EXPOSURE PATHWAY
EXERCISE
EXPERIMENTAL DATA
FORMALDEHYDE
INDOOR AIR POLLUTION
INFORMATION
INHALATION
INTAKE
LUNGS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES