The iron chelator desferrioxamine attenuates postischemic ventricular dysfunction

Journal Article · Mon Nov 30 23:00:00 EST 1987 · American Journal of Physiology; (USA)

OSTI ID:6945534

Bolli, R; Patel, B S; Zhu, Weixi; O'Neill, P G; Hartley, C J; Charlat, M L; Roberts, R ^[1]

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1. Baylor College of Medicine, Houston, TX (US)

Recent evidence suggests that postischemic myocardial dysfunction (stunning) may be mediated by oxygen free radicals, but the mechanism by which they produce myocellular damage remains unknown. Since iron catalyzes formation of hydroxyl radicals (HO{center dot}) as well as HO{center dot}-initiated lipid peroxidation, the authors explored the potential role of this metal in the pathogenesis of myocardial stunning. Open-chest dogs undergoing a 15-min occlusion of the left anterior descending coronary artery (LAD) followed by 4 h of reperfusion (REP) received the iron chelator desferrioxamine intravenously or normal saline. Regional myocardial function was assessed by measuring systolic wall thickening with an epicardial Doppler probe. The two groups exhibited comparable systolic thickening under base-line conditions and similar degrees of dyskinesis during ischemia. After REP, however, recovery of contractile function as considerably greater in desferrioxamine-treated compared with control dogs. These differences could not be ascribed to hemodynamic factors. The results suggest that iron-catalyzed reactions (possibly HO{center dot} generation) play a significant role in myocardial stunning after a brief episode of reversible regional ischemia.

• OSTI ID: 6945534
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:6; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BLOOD FLOW
CARDIOVASCULAR DISEASES
CHELATING AGENTS
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DEFEROXAMINE
DISEASES
DOGS
DOPPLER EFFECT
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
HYDROXYL RADICALS
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MYOCARDIAL INFARCTION
NIOBIUM 95
NIOBIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOGENESIS
RADICALS
RADIOISOTOPES
STRONTIUM 85
STRONTIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES