Antioxidant enzymes attenuate myocardial stunning in the conscious dog

Conference · Mon Feb 26 04:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6140743

Triana, J F; Unisa, A; Bolli, R ^[1]

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1. Baylor Coll. of Medicine, Houston, TX (United States)

Several studies have shown that postischemic myocardial dysfunction (myocardial stunning) is attenuated by antioxidants, implying a pathogenetic role of oxy-radicals in this phenomenon. However, since all these studies have been performed in open-chest preparations, artifacts due to anesthesia, trauma, and other nonphysiologic conditions cannot be excluded. Accordingly, chronically instrumented dogs underwent a 15-minute occlusion (o) of the left anterior descending artery followed by reperfusion. Dogs received i.v. either saline or superoxide dismutase (SOD) plus catalase (CAT) (16,000 U/kg and 55,000 U/kg, respectively, over 1 hour starting 15 minutes before O). Regional myocardial function was assessed as systolic wall thickening (WTh) using a pulsed Doppler probe. WTh after reperfusion was significantly greater in treated dogs, and this difference could not be ascribed to differences in collateral flow or hemodynamics. The authors conclude that SOD plus catalase attenuate myocardial stunning in the conscious dog, indicating that oxy-radicals play a pathogenetic role in this phenomenon under physiologic conditions.

• OSTI ID: 6140743
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 4:3
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATALASE
DISEASES
DOGS
ELEMENTS
ENZYMES
HEART
HEMIC DISEASES
ISCHEMIA
MAMMALS
MUSCLES
MYOCARDIUM
NONMETALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN
PATHOGENESIS
PEROXIDASES
PROTEINS
RADICALS
SUPEROXIDE DISMUTASE
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES