Alterations in glucose kinetics induced by pentobarbital anesthesia
- Louisiana State Univ. Medical Center, New Orleans (USA)
Because pentobarbital is often used in investigations related to carbohydrate metabolism, the in vivo effect of this drug on glucose homeostasis was studied. Glucose kinetics assessed by the constant intravenous infusion of (6-{sup 3}H)- and (U-{sup 14}C)glucose, were determined in three groups of catheterized fasted rats: conscious, anesthetized and body temperature maintained, and anesthetized but body temperature not maintained. After induction of anesthesia, marked hypothermia developed in rats not provided with external heat. Anesthetized rats that developed hypothermia showed a decrease in mean arterial blood pressure (25%) and heart rate (40%). Likewise, the plasma lactate concentration and the rates of glucose appearance, recycling, and metabolic clearance were reduced by 30-50% in the hypothermic anesthetized rats. Changes in whole-body carbohydrate metabolism were prevented when body temperature was maintained. Because plasma pentobarbital levels were similar between the euthermic and hypothermic rats during the first 2 h of the experiment, the rapid reduction in glucose metabolism in this latter group appears related to the decrease in body temperature. The continuous infusion of epinephrine produced alterations in glucose kinetics that were not different between conscious animals and anesthetized rats with body temperature maintained. Thus pentobarbital-anesthetized rats became hypothermic when kept at room temperature and exhibited marked decreases in glucose metabolism. Such changes were absent when body temperature was maintained during anesthesia.
- OSTI ID:
- 6945441
- Journal Information:
- American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:6; ISSN 0002-9513; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats
Effects of vasoactive intestinal peptide on vascular conductance are unaffected by anesthesia
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
ALDEHYDES
ANESTHESIA
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BARBITURATES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
FASTING
GLUCOSE
HETEROCYCLIC COMPOUNDS
HEXOSES
HYDROGEN COMPOUNDS
HYDROXY ACIDS
HYPNOTICS AND SEDATIVES
KINETICS
LABELLED COMPOUNDS
LACTIC ACID
MAMMALS
METABOLISM
MONOSACCHARIDES
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PHENOBARBITAL
PHYSIOLOGY
PYRIMIDINES
RATS
REACTION KINETICS
RODENTS
SACCHARIDES
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
VERTEBRATES