Influence of attenuation on radionuclide stroke volume determinations

Journal Article · Wed Sep 01 04:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6943387

Burow, R D; Wilson, M F; Heath, P W; Corn, C R; Amil, A; Thadani, U

Using a method for determination of absolute volumes, including correcting for attenuation, we have explored the ability of the method to determine stroke volume in humans by radionuclide techniques. Thermodilution cardiac output determinations and multigated equilibrium blood-pool scintigraphy in the LAO view were performed simultaneously in twenty patients in which no evidence of intracardiac shunts or valvular disease was present. The correlation was good between the attenuated radionuclide and thermodilution stroke volume (r . 0.80, s.e.e. of estimate . 12 ml; SVtd . 2.31 x SVr + 18 ml). When correction for attenuation was made, the correlation improved (r . 0.96, s.e.e. . 6 ml) and approached the line of identity (SVtd . 0.99 x SVr + 1.2 ml). The correlation was also good between radionuclide cardiac output, corrected for attenuation, and the thermodilution cardiac output (r . 0.89, s.e.e. . 0.36 l/min; COtd . 0.86 x COr + 0.67 l/min). Thus our method of correction for attenuation in the determination of absolute left-ventricular volumes has been shown to provide a reliable, noninvasive means of calculating stroke volume and cardiac output in humans, without the use of geometric assumptions or regression equations.

• Research Organization: University of Oklahoma Health Sciences Center
• OSTI ID: 6943387
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ATTENUATION
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD CIRCULATION
BODY
BODY FLUIDS
CALCULATION METHODS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DYNAMIC FUNCTION STUDIES
ERYTHROCYTES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PHYSIOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
VOLUME
YEARS LIVING RADIOISOTOPES