Biological (molecular and cellular) markers of toxicity

Technical Report · Sun Apr 01 00:00:00 EST 1990

DOI:https://doi.org/10.2172/6943031· OSTI ID:6943031

McCarthy, J F

The overall objective of this study is to evaluate the use of the small aquarium fish, Japanese Medaka, as a predictor of potential genotoxicity following exposure to carcinogens. This will be accomplished by quantitatively investigating the early molecular events associated with genotoxicity of various tissues of Medaka subsequent to exposure of the organism to several known carcinogens, such as diethylnitrosamine (DEN) and benzo(a)pyrene (BaP). 11 refs., 1 fig., 1 tab.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOD
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6943031
• Report Number(s): ORNL/M-1143; ON: DE90011290
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGENS
TOXICITY
FISHES
BIOASSAY
NITROSAMINES
ANIMAL TISSUES
BIOLOGICAL INDICATORS
BIOLOGICAL MARKERS
CARCINOGENESIS
DOSE-RESPONSE RELATIONSHIPS
LIVER
MOLECULAR BIOLOGY
NEOPLASMS
PROGRESS REPORT
QUANTITATIVE CHEMICAL ANALYSIS
AMINES
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BODY
CHEMICAL ANALYSIS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DISEASES
DOCUMENT TYPES
GLANDS
HYDROCARBONS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
TISSUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology