Biological (molecular and cellular) markers of toxicity: Semi-annual technical progress report (No. 1), October 1, 1988--March 31, 1989

Technical Report · Sat Apr 01 04:00:00 EST 1989

DOI:https://doi.org/10.2172/6225771· OSTI ID:6225771

McCarthy, J. F.

The overall objective of this study is to evaluate the use of a small aquarium fish, the Japanese Medaka, as a predictor of potential health effects following exposure to the carcinogen diethyl nitrosamine (DEN). Research efforts will investigate the dose response relationship that exists between a suite of molecular parameters and the carcinogenic agent with respect to external dose, dose at the target organ/tissue, appearance of preneoplastic lesions and foci, and the occurrence of tumors. The two tasks that are being pursued this fiscal year are: to evaluate, in the liver of the Japanese Medaka exposed to the carcinogen DEN, the integrity of DNA and the status of the detoxification system (biotransformation capabilities); and to evaluate the kinetics of formation of various liver cell types subsequent to exposure to DEN. 2 refs., 2 figs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6225771
• Report Number(s): ORNL/M-829; ON: DE89012365
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL MARKERS
BODY
CARCINOGENS
DIGESTIVE SYSTEM
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
FISHES
GLANDS
LIVER
MOLECULAR BIOLOGY
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROGRESS REPORT
VERTEBRATES