Effects of the environmental pollutants on heme oxygenase activity and cytochrome P-450 content in fish

Journal Article · Thu Feb 01 04:00:00 EST 1990 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01700135· OSTI ID:6943023

Ariyoshi, Toshihiko; Shiiba, Seiichi; Hasegawa, Hiroyuki; Arizono, Koji ^[1]

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1. Nagasaki Univ. (Japan)

It is well established that fish have the ability to metabolize foreign compounds in a similar manner to that of mammalian species. In addition, it is well known that many environmental and hereditary factors cause changes in the activity of microsomal drug metabolizing enzymes in mammals. However, very little is known in fish about the effects of environmental contaminants on the relationship between the activity of heme oxygenase, and the content of hemoprotein namely cytochrome P-450. Therefore, in the present study, the authors have investigated the activities of heme oxygenase as well as other drug metabolizing enzymes and the content of P-450 in the hepatopancreas of fish as the biochemical indicator, and thereby have made an attempt to clarify the range of pollution in the aquatic environment.

• OSTI ID: 6943023
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 44:2; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CYTOCHROMES
DIGESTIVE SYSTEM
ENDOCRINE GLANDS
ENZYMES
FISHES
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEME
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LIVER
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PANCREAS
PESTICIDES
PIGMENTS
POLLUTION
PORPHYRINS
PROTEINS
SULFONATES
SURFACTANTS
VERTEBRATES
WATER POLLUTION