Profile of metal-binding proteins and heme oxygenase in red carp treated with heavy metals, pesticides and surfactants

Journal Article · Sun Apr 01 04:00:00 EDT 1990 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01700889· OSTI ID:6521631

Ariyoshi, Toshihiko; Shiiba, Seiichi; Hasegawa, Hiroyuki; Arizono, Koji ^[1]

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1. Nagasaki Univ. (Japan)

A family of hemoproteins known as cytochrome P-450, which is known to perform a major role in the metabolism of various agents, has been investigated in fish as a criterion for monitoring water pollution. This enzyme is well known to be induced by various chemicals in fish as well as mammals. However, very little information is available concerning the effects of environmental pollutants on the activity of heme oxygenase, the first and rate-limiting enzyme for heme degradation. To investigate the nature of heme oxygenase is of particular interest in that if heme oxygenase activity is altered by contaminants, that may contribute to the effect on physiological changes of heme and hemoprotein P-450. In this study the authors investigated the effects of heavy metals, pesticides and surfactants on the MBP and the heme oxygenase in the hepatopancreas and kidney of a fresh water red carp (Cyprinus carpio Linne).

• OSTI ID: 6521631
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 44:4; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ANIMALS
AQUATIC ORGANISMS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
ELEMENTS
ENDOCRINE GLANDS
ENZYMES
FISHES
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEME
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
KIDNEYS
LEAD COMPOUNDS
LIVER
METALLOPROTEINS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGENASES
PANCREAS
PESTICIDES
PIGMENTS
PORPHYRINS
PROTEINS
SURFACTANTS
VERTEBRATES